[Leanpub.com][1] accepts Markdown only from authors. They use [some extensions][2] like tables or source code embedding to take most of the pain away. Markdown doesn’t such a fine control as TeX/LaTeX, but most ebook readers wouldn’t honor that anyway. You can take a look at the free sample ([example][3]) to judge the result. I think, yes, Markdown is an excellent format to write ebooks. [1]: https://leanpub.com [2]: https://leanpub.com/help/manual#leanpub-auto-markdown-the-easiest-way-to-format-your-text-for-e-publishing [3]: https://leanpub.com/software-architecture-for-developers