It is not usual for technology or to play a title role in works of fiction. Air Force One (1997) as an example. I am not looking for work that is both an ebook and a movie. I am looking for something like Attack of the Killer (ereader brand)'. Or the The (ebook title) that changed the World
One of the most famous is The Hitchhiker's Guide To The Galaxy, which is a travel guide that is mentioned periodically in the novel of the same name (and also its sequels) by Douglas Adams.
"The Diamond Age: Or, A Young Lady's Illustrated Primer" by Neal Stephenson is heavily focussed on the eponymous ebook reader.
At the age of four, Nell receives a stolen copy of an interactive book, Young Lady's Illustrated Primer: a Propædeutic Enchiridion in which is told the tale of Princess Nell and her various friends, kin, associates, &c., originally intended for an aristocrat's child in the Neo-Victorian New Atlantis phyle. The story follows Nell's development under the tutelage of the Primer, and to a lesser degree, the lives of Elizabeth and Fiona, girls who receive similar books. The Primer is intended to steer its reader intellectually toward a more interesting life, as defined by "Equity Lord" Alexander Chung-Sik Finkle-McGraw, and growing up to be an effective member of society. The most important quality to achieving an "interesting life" is deemed to be a subversive attitude towards the status quo. The Primer is designed to react to its owners' environment and teach them what they need to know to survive and develop.
Interestingly, the book almost certainly inspired the development of real-world ebook readers...
The closest example that I can think of is in I, Robot... You, Jane, an episode of Buffy the Vampire Slayer. In this episode there is an old book which contains the life force of a demon. It is scanned in to a computer, releasing the demon into the computer network.